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Circulating immune complexes in cynomolgus macaques.

N J Alexander, T B Clarkson, D L Fulgham

    Laboratory Animal Science
    |October 1, 1985
    PubMed
    Summary
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    Circulating immune complexes (CICs) are common in cynomolgus macaques. CIC levels vary significantly by country of origin and age, impacting their use in disease research.

    Area of Science:

    • Veterinary Immunology
    • Primate Models
    • Immunopathology

    Background:

    • Nonhuman primates are valuable models for immune-complex-associated diseases.
    • Limited data exists on circulating immune complexes (CICs) in healthy cynomolgus macaques.

    Purpose of the Study:

    • To quantify CIC levels in a large cohort of cynomolgus macaques.
    • To identify factors influencing CIC prevalence in these animals.

    Main Methods:

    • Serum samples from 313 adult and 106 juvenile cynomolgus macaques (Macaca fascicularis) were analyzed.
    • Three distinct assays were employed to measure CIC levels.
    • Statistical analysis was performed to assess associations with origin and age.

    Main Results:

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    • A higher than expected prevalence of CICs was detected across the cohort.
    • Significant statistical association found between CIC levels and country of origin (Indonesia, Malaya, Philippines).
    • Juvenile macaques exhibited lower CIC levels compared to adults.

    Conclusions:

    • Country of origin and age are critical factors influencing CIC levels in cynomolgus macaques.
    • These factors must be considered when selecting macaques for research on immune-complex-associated diseases.
    • Genetic factors may also play a role in CIC prevalence.