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Related Experiment Videos

Customized vascular catheters for rodents.

D F Brown, R E Burr

    Laboratory Animal Science
    |October 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Researchers developed custom rodent catheters from polyurethane tubing, a material noted for low thrombogenicity and toxicity. These easily fabricated and sealed catheters maintained patency without flushing, offering a practical solution for chronic vascular access in small animals.

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    Area of Science:

    • Biomedical Engineering
    • Materials Science
    • Veterinary Medicine

    Background:

    • Chronic vascular access in rodents is crucial for research.
    • Existing catheter materials may present challenges with thrombogenicity, toxicity, or fabrication.
    • A need exists for reliable, cost-effective, and easily prepared catheter systems.

    Purpose of the Study:

    • To describe the fabrication and implementation of custom polyurethane catheters for rodents.
    • To evaluate the suitability of polyurethane as a material for chronic vascular access devices.
    • To establish a method for maintaining catheter patency in vivo.

    Main Methods:

    • Custom arterial and venous catheters were fabricated from polyurethane tubing.
    • Polyurethane tubing was shaped using heated peanut oil (160°C).

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  • Catheter ends were sealed by heating and manual pinching.
  • Chronic catheter patency was maintained using Burr's solution (9:1 glycerine and heparin mixture).

    • Main Results:

    • Polyurethane demonstrated low thrombogenicity and toxicity, making it an ideal catheter material.
    • The fabrication and sealing methods were simple and effective.
    • Chronic catheter patency was successfully maintained without the need for regular flushing.
    • The developed catheters proved suitable for long-term use in rodents.

    Conclusions:

    • Custom polyurethane catheters offer a practical and effective solution for chronic vascular access in rodent models.
    • The material properties and fabrication techniques facilitate the creation of reliable and low-maintenance vascular access devices.
    • This method provides a valuable tool for researchers requiring long-term intravenous or arterial access in small animals.