Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioreactor Controls-III01:22

Bioreactor Controls-III

Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...
Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Component library creation and pixel array generation with micromilled droplet microfluidics.

Microsystems & nanoengineering·2025
Same author

Partitioning of a 2-bit hash function across 66 communicating cells.

Nature chemical biology·2024
Same author

GOLDBAR: A Framework for Combinatorial Biological Design.

ACS synthetic biology·2024
Same author

Design automation of microfluidic single and double emulsion droplets with machine learning.

Nature communications·2024
Same author

Ten simple rules for managing laboratory information.

PLoS computational biology·2023
Same author

Versatility and stability optimization of flow-focusing droplet generators <i>via</i> quality metric-driven design automation.

Lab on a chip·2023
Same journal

Retargeted serine integrases for one-step, precise integration of large DNA sequences in human cells.

Nature biotechnology·2026
Same journal

A retargeted recombinase for precise insertion of large DNA.

Nature biotechnology·2026
Same journal

Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles.

Nature biotechnology·2026
Same journal

Spatially resolved profiling of extracellular vesicles in tissues with Spatial-EV-seq.

Nature biotechnology·2026
Same journal

Mapping the spatial landscape of extracellular vesicles in tissues with Spatial-EV-seq.

Nature biotechnology·2026
Same journal

Author Correction: Generation of modified cows and sheep from spermatid-like haploid embryonic stem cells.

Nature biotechnology·2026
See all related articles

Related Experiment Video

Updated: Jun 25, 2026

BioMEMS: Forging New Collaborations Between Biologists and Engineers
07:26

BioMEMS: Forging New Collaborations Between Biologists and Engineers

Published on: November 1, 2007

8.2K

Improving engineered biological systems with electronics and microfluidics.

Rabia Tugce Yazicigil1,2,3, Akshaya Bali4, Dilara Caygara4,5

  • 1Electrical and Computer Engineering Department, Boston University, Boston, MA, USA. rty@bu.edu.

Nature Biotechnology
|June 27, 2025
PubMed
Summary
This summary is machine-generated.

Engineered biological systems merge electronics with biology for sensing and acting in environments. This review details their applications, design, and challenges, offering a framework for future development.

More Related Videos

Bridging the Bio-Electronic Interface with Biofabrication
16:38

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

16.9K
Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
14:48

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Published on: April 17, 2021

4.2K

Related Experiment Videos

Last Updated: Jun 25, 2026

BioMEMS: Forging New Collaborations Between Biologists and Engineers
07:26

BioMEMS: Forging New Collaborations Between Biologists and Engineers

Published on: November 1, 2007

8.2K
Bridging the Bio-Electronic Interface with Biofabrication
16:38

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

16.9K
Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device
14:48

Generation of Dynamical Environmental Conditions using a High-Throughput Microfluidic Device

Published on: April 17, 2021

4.2K

Area of Science:

  • Biotechnology and Synthetic Biology
  • Bioengineering
  • Environmental Science

Background:

  • Hybrid engineered biological systems integrate electronic and microfluidic components with biological elements like microbes or cell-free DNA systems.
  • These systems are crucial for addressing complex challenges in healthcare, environmental monitoring, remediation, and agriculture.

Purpose of the Study:

  • To provide an in-depth discussion of the applications, design choices, and challenges of hybrid engineered biological systems.
  • To present a classification framework for informed design decisions in biological applications.
  • To explore the development of cyber-secure biological systems for enhanced functionality and security.

Main Methods:

  • Review of current literature and state-of-the-field analysis.
  • Development of a novel classification framework for engineered biological systems.
  • Discussion of cyber-security considerations for biological platforms.

Main Results:

  • Comprehensive overview of the diverse applications of hybrid engineered biological systems.
  • A structured framework to guide the design and optimization of these systems for specific biological tasks.
  • Identification of key challenges and future directions, including cyber-security.

Conclusions:

  • Hybrid engineered biological systems are essential tools with broad applications across multiple sectors.
  • Informed design choices, guided by a classification framework, are critical for optimizing system performance.
  • Advancements in cyber-secure biological systems will enhance the reliability and functionality of future engineered platforms.