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Formulation Development and Characterization of Bigels Containing Curcumin for Topical Skin Delivery
Lord Sam Liston1, Suranate Phanapithakkun1,2, Nuttakul Pimsarn1
1School of Pharmacy, Walailak University, 222 Thaiburi, Nakhon Si Thammarat, 80161, Thasala, Thailand.
AAPS Pharmscitech
|June 27, 2025
Summary
This study developed a novel curcumin bigel formulation (BG30) to improve curcumin
Area of Science:
- Dermatology and Pharmaceutical Sciences
- Materials Science and Engineering
Background:
- Curcumin exhibits beneficial skin properties like anti-inflammation and wound healing.
- Poor skin penetration limits curcumin's topical efficacy.
- Bigels, combining hydrogel and organogel properties, offer enhanced delivery systems.
Purpose of the Study:
- To formulate and characterize curcumin-loaded bigels for improved topical delivery.
- To evaluate the skin deposition, safety, and wound healing potential of the bigels.
Main Methods:
- Curcumin bigels (BG50, BG40, BG30) were prepared using HPMC hydrogel and Span® 60/almond oil organogel.
- Bigels were characterized for physical properties, skin permeation, and in vitro cytotoxicity.
- Wound healing efficacy was assessed using a murine fibroblast cell line (L929) scratch assay.
Main Results:
- BG30 formulation showed optimal characteristics for topical delivery.
- BG30 significantly enhanced curcumin accumulation in skin layers compared to organogel.
- All bigels were non-toxic, and BG30 demonstrated superior wound healing capabilities.
Conclusions:
- The developed BG30 bigel formulation effectively enhances curcumin's skin deposition and therapeutic potential.
- BG30 shows promise as a topical delivery system for curcumin in treating skin conditions and promoting wound healing.
