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Multifunctional Bioactive Cu-Sm-Based Nanozyme Systems for Psoriasis Therapy.

Hui Yuan1,2,3,4, Jiangshan Hu1,2,3,4, Hao Sun2,3,4

  • 1School of Chemistry and Chemical Engineering/Jiangxi Provincial Key Laboratory of Functional Molecular Materials Chemistry, Jiangxi University of Science and Technology, Ganzhou, Jiangxi 341000, P. R. China.

ACS Biomaterials Science & Engineering
|June 28, 2025
PubMed
Summary

Copper-samarium nanozymes show promise for psoriasis treatment by reducing inflammation and oxidative stress. These novel nanoparticles offer a potentially safer and more effective alternative to current therapies for this chronic skin condition.

Keywords:
ROS scavengingnanozymepsoriasisreactive oxygen species (ROS)samarium

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Dermatology

Background:

  • Psoriasis is a widespread inflammatory skin disease with limited effective treatments.
  • Current therapies often have significant side effects and variable efficacy.

Purpose of the Study:

  • To develop and evaluate a novel copper-samarium (Cu-Sm) bimetallic nanozyme (CS NPs) for psoriasis treatment.
  • To investigate the antioxidant and anti-inflammatory properties of CS NPs.

Main Methods:

  • Synthesized and characterized CS NPs for stability and catalytic activity.
  • Assessed CS NP effects on reactive oxygen species (ROS) and inflammatory pathways in vitro (HaCaT cells).
  • Evaluated CS NP efficacy in ameliorating imiquimod (IMQ)-induced psoriasis-like skin lesions in mouse models.

Main Results:

  • CS NPs demonstrated potent antioxidant activity, neutralizing key reactive oxygen species.
  • In vitro studies showed CS NPs reduced ROS, inhibited keratinocyte proliferation, and suppressed inflammatory cytokines via NF-κB pathway.
  • In vivo, CS NPs effectively reduced psoriasiform lesion severity in mice by decreasing epidermal thickening and inflammatory markers.

Conclusions:

  • Cu-Sm bimetallic nanozymes possess significant antioxidant and anti-inflammatory capabilities.
  • CS NPs show therapeutic potential for psoriasis, offering a biocompatible alternative to conventional treatments.