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In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
Published on: September 28, 2017
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Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironment
Taoxing Peng1,2,3, Yiqi Wan1,2,3,4, Yuxuan Sun1,2
1The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Department of Pathology and Institute of Molecular Pathology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Gut Microbes
|June 28, 2025
Summary
Circadian rhythm dysfunction disrupts the gut microbiota and tumor microenvironment. Targeting this axis offers new therapeutic strategies for cancer treatment.
Area of Science:
- Oncology
- Microbiology
- Chronobiology
Background:
- Circadian rhythms regulate physiological processes, and their dysfunction is linked to cancer.
- Alterations in gut microbiota (GM) and tumor microenvironment (TME) are associated with circadian rhythm disruption.
- The interplay between circadian rhythms, GM, and TME is crucial for cancer development and progression.
Purpose of the Study:
- To review the impact of circadian dysfunction on GM and TME dynamics.
- To emphasize the relationship between circadian rhythms and GM.
- To explore therapeutic strategies leveraging the circadian-GM interplay for TME normalization and improved clinical outcomes.
Main Methods:
- Literature review focused on circadian rhythms, gut microbiota, and tumor microenvironment.
- Analysis of existing research on circadian dysfunction and its effects.
- Exploration of therapeutic interventions targeting the circadian-GM axis.
Main Results:
- Circadian dysfunction significantly impacts the gut microbiota and tumor microenvironment.
- A novel "rhythms-microbiota-microenvironment axis" is proposed, linking these components.
- The interplay between circadian rhythms and GM presents potential therapeutic avenues.
Conclusions:
- Circadian rhythm disruption negatively affects the rhythms-microbiota-microenvironment axis.
- Therapeutic strategies modulating the circadian-GM interplay may normalize the TME.
- Further research into this axis could lead to innovative cancer therapies.
Keywords:
Circadian rhythmsgut microbiotametabolitesrhythms-microbiota-microenvironment axistumor microenvironmentMore Related Videos
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