Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

129
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
129
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

225
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
225
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

173
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
173
Depression: Overview01:18

Depression: Overview

361
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
361
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

299
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
299
Long-term Depression01:03

Long-term Depression

2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Six-month outcomes of a multidomain RCT lifestyle and memory support intervention among older adults with subjective cognitive decline (Brain Boosters).

International psychogeriatrics·2026
Same author

Achieving Beta-Lactam Goals During the Critical Collision of ARC in OLT Patients.

Transplant infectious disease : an official journal of the Transplantation Society·2026
Same author

Structural and load-dependent arterial stiffness are differentially associated with cognition or biomarkers of Alzheimer's disease and related dementias: The healthy brain study.

Journal of Alzheimer's disease : JAD·2026
Same author

Low-fat dietary pattern and dementia mortality: a secondary analysis of the Women's Health Initiative dietary modification randomized clinical trial with long-term follow-up.

Menopause (New York, N.Y.)·2026
Same author

Purpose in life, personal growth, life satisfaction and risk of cognitive impairment among older women.

Aging & mental health·2026
Same author

Association of neighborhood deprivation with Alzheimer's Disease pathology, brain structure, and cognition by race and ethnicity, sex, and APOE ε4 status.

medRxiv : the preprint server for health sciences·2026
Same journal

Diagnosis of Alzheimer's disease and related dementias and outmigration of older Puerto Rican Medicare Fee-for-service beneficiaries, 2012-2019.

The journals of gerontology. Series B, Psychological sciences and social sciences·2026
Same journal

Inflammatory biomarkers are associated with spatial navigation in older adults.

The journals of gerontology. Series B, Psychological sciences and social sciences·2026
Same journal

Independent trajectories of cognitive function and daily events across nine years during midlife and old age.

The journals of gerontology. Series B, Psychological sciences and social sciences·2026
Same journal

Are associations between relationship satisfaction, emotional intimacy, and successful sexual aging gender-specific?

The journals of gerontology. Series B, Psychological sciences and social sciences·2026
Same journal

Bidirectional longitudinal associations of family/friend social support with cognitive function in late life.

The journals of gerontology. Series B, Psychological sciences and social sciences·2026
Same journal

How Do Limited Familial Ties and Community Relationships Shape Health-Seeking in Older Adulthood? Evidence from Indonesia.

The journals of gerontology. Series B, Psychological sciences and social sciences·2026
See all related articles

Related Experiment Video

Updated: Sep 17, 2025

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

815

Depressive symptoms and cognitive function in the U.S. POINTER study.

Kristin R Krueger1, Katelyn Garcia2, Sarah Tomaszewski Farias3

  • 1Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, United States.

The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
|June 28, 2025
PubMed
Summary
This summary is machine-generated.

Depressive symptoms, even mild, were linked to slower processing speed in older adults. This cognitive change may be an early sign of depression, impacting daily functioning.

Keywords:
cognitive declinedementiageriatric depressionmoodprocessing speed

More Related Videos

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

7.4K
A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

21.2K

Related Experiment Videos

Last Updated: Sep 17, 2025

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

815
Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

7.4K
A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

21.2K

Area of Science:

  • Neuroscience
  • Gerontology
  • Psychiatry

Background:

  • The association between depressive symptoms and cognitive decline is well-established in older adults.
  • The U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) investigates lifestyle impacts on cognition in at-risk older adults.

Purpose of the Study:

  • To assess the relationship between depressive symptoms and cognitive functioning at baseline in U.S. POINTER participants.
  • To determine if depressive symptoms, even subclinical, correlate with specific cognitive domains in a diverse older adult population.

Main Methods:

  • Examined 2,103 participants (aged 60-79) from the U.S. POINTER study.
  • Assessed cognition using the Neuropsychological Test Battery (episodic memory, executive functioning, processing speed, global cognition) and depression via the Geriatric Depression Scale (GDS-15).
  • Employed linear regression models, controlling for demographics, to analyze the association between GDS-15 scores and cognitive composite scores.

Main Results:

  • Higher continuous GDS-15 scores correlated with lower global cognition and slower processing speed.
  • No significant association was found with episodic memory or executive functioning when GDS-15 was treated continuously.
  • When using clinical cut-offs for GDS-15, only processing speed showed an association, even after adjusting for multiple demographic factors.

Conclusions:

  • Depressive symptoms, including low and subclinical levels, are associated with slower processing speed in a diverse group of community-dwelling older adults.
  • Slowed processing speed may be an early cognitive indicator of depression in older individuals, consistent with existing research.
  • These findings highlight the importance of monitoring depressive symptoms for cognitive health in aging populations.