Related Experiment Video
Updated: Sep 17, 2025

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
Effects of booster vaccination on post-treatment oxygen deterioration in hospitalized mild-to-moderate COVID-19
Shunsaku Hayai1, Kensuke Fukumitsu2, Atsushi Suzuki3
1Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan; Department of Internal Medicine, Aichi Prefectural Hospital, Okazaki, Aichi, Japan.
Introduction:
Although the emergence of the Omicron variant has decreased overall mortality from Coronavirus Disease 2019 (COVID-19) compared to the Delta variant, elderly individuals with comorbidities remain at increased risk of adverse outcomes. While vaccination and antiviral treatments have reduced the severity of COVID-19, data on the impact of booster vaccination on post-hospitalization oxygen deterioration in the Japanese population remain limited.
Methods:
We conducted a retrospective study of hospitalized mild-to-moderate COVID-19 Japanese patients during the Omicron variant wave (December 2021 to October 2022). Both vaccinated and unvaccinated patients were included and categorized into three groups based on their vaccination status: unvaccinated (0-1 vaccine dose), primary series (2 vaccine doses), and booster group (3-4 vaccine doses). Demographic and clinical data were collected, and the frequency and time to post-hospitalization oxygen deterioration were evaluated among the three groups.
Results:
A total of 596 patients were analyzed (141 unvaccinated, 180 primary series, and 275 booster group). The booster group showed significantly lower rates of oxygen deterioration and a longer time to deterioration compared to the other groups, despite being older and having more comorbidities. A multivariate analysis, adjusted for age and gender, revealed that booster vaccination was significantly associated with a reduced risk of oxygen deterioration after initial treatment. Similar results were observed in the subgroup analysis of elderly patients aged 65 years and older.
Conclusion:
Our study demonstrated the effectiveness of booster vaccination on preventing post-treatment oxygen deterioration in hospitalized mild-to-moderate COVID-19 Japanese patients with comorbidities during the Omicron wave.
More Related Videos
Related Concept Videos
COPD: Management Using Bronchodilators and Corticosteroids
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Pneumonia III: Complications and Assessment
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Acute Respiratory Failure-III

