Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

4.1K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.1K
Sample Handling01:02

Sample Handling

3.0K
Transportation of samples from the collection point to the laboratory, as well as storage and preservation techniques, are crucial for maintaining sample integrity and ensuring accurate and reliable test results.
Samples should be transported carefully from collection points to the laboratory. They should be properly sealed and clearly labeled to prevent cross-contamination. To preserve the sample integrity, optimal temperature conditions during transport are essential. This could involve using...
3.0K
Semiconductors01:22

Semiconductors

1.8K
There is variation in the electrical conductivity of materials - metals, semiconductors, and insulators that are showcased with the help of the energy band diagrams.
Metals such as copper (Cu), zinc (Zn), or lead (Pb) have low resistivity and feature conduction bands that are either not fully occupied or overlap with the valence band, making a bandgap non-existent. This allows electrons in the highest energy levels of the valence band to easily transition to the conduction band upon gaining...
1.8K
Hepatic Portal System01:21

Hepatic Portal System

8.2K
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
8.2K
Liver Physiology01:30

Liver Physiology

3.8K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.8K
iChip01:24

iChip

105
The cultivation of environmental microorganisms has long been hindered by the inability to replicate complex native conditions in vitro. The isolation chip (iChip) addresses this limitation by facilitating the growth of previously uncultivable microorganisms through in situ incubation. Designed for high-throughput microbial cultivation, the iChip comprises hundreds of microchambers, each capable of housing a single microbial cell. These microchambers are loaded with a mixture of molten agar and...
105

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fabrication of hybrid PCL-Chitosan/PVA nanofibers by hybrid electrospinning for Local melanoma skin cancer therapy.

Scientific reports·2026
Same author

Comparing Disease-Free Survival (DFS) and Overall Survival (OS) Rates in Breast Cancer Patients: Axillary Lymph Node Dissection (ALND) Versus Sentinel Lymph Node Biopsy (SLNB).

International journal of breast cancer·2026
Same author

Autophagy-centered gene networks reveal prognostic biomarkers and therapeutic targets in esophageal cancer.

Discover oncology·2026
Same author

A case of cystic brain metastasis from lung adenocarcinoma.

Caspian journal of internal medicine·2026
Same author

Computational design of a multi-epitope vaccine against Helicobacter pylori targeting CagA, FliD, urease, and OipA with cholera toxin B subunit (CTB) adjuvant.

BMC microbiology·2026
Same author

A mechanical reprogramming: synergistic tumor microenvironment normalization improves nano-immunotherapy delivery in prostate cancer via multiphysics modeling.

Drug delivery and translational research·2026
Same journal

A Physiologic Left Ventricle Flow Phantom for 4D Flow MRI Applications and CFD Verification.

Annals of biomedical engineering·2026
Same journal

Pulsatile Hemodynamics of Prehypertension and Hypertension: Associations with Pressure and Sex.

Annals of biomedical engineering·2026
Same journal

A Pressure Difference-Based Strategy for Blood Oxygen Control in Membrane Oxygenators: Reduced Modeling, Computational Simulation, and Exploratory In Vivo Evaluation.

Annals of biomedical engineering·2026
Same journal

Multidirectional Optical Bone Densitometry Using a Simulation-Based Machine Learning Model: Experimental Validation with Bone Phantoms.

Annals of biomedical engineering·2026
Same journal

Numerical Study of Human Torso Mechanical Response and Injury Assessment Under Blast Loading with Bulletproof Protection.

Annals of biomedical engineering·2026
Same journal

Immediate and Mid-Long-Term Effects of Foot Orthoses on Gait Biomechanics and Clinical Characteristics in Medial Knee Osteoarthritis: A Systematic Review and Meta-analysis.

Annals of biomedical engineering·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
10:05

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

29.0K

Lessons Learned from Liver-on-Chip Platform.

Zahra Sadat Razavi1,2, Fateme Sadat Razavi3, Madjid Soltani4,5,6,7,8

  • 1Physiology Research Center, Iran University Medical Sciences, Tehran, Iran.

Annals of Biomedical Engineering
|June 28, 2025
PubMed
Summary
This summary is machine-generated.

Advancements in experimental liver models, from 2D cultures to 3D systems and livers on a chip (LioCs), offer better insights into liver diseases and drug screening by mimicking the liver microenvironment.

Keywords:
In vitro modelLiver metabolismLiver-on-ChipOrgan-on-a-Chip

More Related Videos

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
10:25

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

Published on: February 19, 2019

11.6K
Generation of a Human iPSC-Based Blood-Brain Barrier Chip
10:20

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

12.8K

Related Experiment Videos

Last Updated: May 4, 2026

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
10:05

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

29.0K
"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection
10:25

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

Published on: February 19, 2019

11.6K
Generation of a Human iPSC-Based Blood-Brain Barrier Chip
10:20

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

12.8K

Area of Science:

  • * Hepatology and in vitro modeling
  • * Biomedical engineering and tissue engineering

Background:

  • * The liver's central role in metabolism necessitates accurate in vitro models for research.
  • * Traditional 2D liver models lack the three-dimensional complexity of the natural hepatic milieu.
  • * Limitations of 2D models hinder the accurate study of liver pathophysiology.

Purpose of the Study:

  • * To review the evolution of experimental liver models.
  • * To highlight the development of 3D liver culture strategies and livers on a chip (LioCs).
  • * To emphasize the improved physiological relevance of newer models for disease and drug studies.

Main Methods:

  • * Discussion of traditional 2D hepatocyte models.
  • * Exploration of advanced 3D liver culturing techniques.
  • * Analysis of livers on a chip (LioCs) incorporating fluid dynamics.

Main Results:

  • * 3D models better replicate the liver's cellular interplay and microenvironment.
  • * Livers on a chip (LioCs) simulate physiological fluid flow, enhancing hepatic functions.
  • * LioCs demonstrate significant utility in pathophysiology modeling, tissue engineering, and drug screening.

Conclusions:

  • * The progression from 2D to 3D and LioC models represents a significant leap in mimicking the liver's in vivo environment.
  • * Advanced models are crucial for accurate liver disease research and effective drug development.
  • * LioCs offer a powerful platform for high-throughput, physiologically relevant liver studies.