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Sleep disorders accelerate biological aging through depressive symptoms: Evidence from NHANES
Zheng Zhang1,2, Huijie Xu3, Liping Cui4
1Key Laboratory of Brain, Cognition and Education Sciences, South China Normal University, Ministry of Education, Guangzhou, China.
Journal of Health Psychology
|June 29, 2025
Summary
Sleep disorders accelerate biological aging, with depression as a mediator. A healthy lifestyle can reduce these effects, promoting longevity.
Area of Science:
- Gerontology and Sleep Science
- Public Health and Epidemiology
Background:
- Sleep disorders are prevalent and linked to adverse health outcomes.
- Biological aging is a complex process influenced by various factors.
- Depressive symptoms and lifestyle choices may interact with sleep disorders.
Purpose of the Study:
- To investigate the impact of sleep disorders on biological aging.
- To examine the mediating role of depressive symptoms.
- To assess the moderating effect of a healthy lifestyle.
Main Methods:
- Utilized data from the National Health and Nutrition Examination Survey (NHANES) (2005-2014).
- Included 18,862 participants aged 20-79.
- Assessed biological aging (Klemera-Doubal method), depressive symptoms (PHQ-9), and lifestyle factors (smoking, alcohol, physical activity).
Main Results:
- Sleep disorders significantly accelerated biological aging (B=4.347, p<0.001).
- Depressive symptoms mediated this relationship (indirect effect B=1.127, p<0.001).
- A healthy lifestyle moderated the effects, reducing both depression and biological aging (B=-0.205, p<0.001).
Conclusions:
- Sleep disorders are a significant risk factor for accelerated biological aging.
- Addressing sleep disorders and promoting healthy lifestyles are crucial for healthy aging and longevity.
- Depression and lifestyle factors play key roles in the relationship between sleep and aging.
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