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Updated: Sep 17, 2025

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
Role of non-coding RNAs in human-papillomavirus-associated cutaneous neoplasms
Niloofar Faraji1, Hassan Vahidnezhad2, Narges Eslami1
1Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Abstract:
The increasing prevalence of skin cancers, including squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and melanoma, is driven by a multifaceted interaction of genetic, epigenetic, and environmental influences, with human papillomavirus (HPV) infection playing a notable role in some cases. This review explores the connection between HPV and host non-coding RNAs (ncRNAs), focusing on their involvement in skin cancer development, and emphasizes the pivotal role of ncRNAs in regulating both viral replication and oncogenic processes within host cells. We discuss the ways in which HPV exploits host cell ncRNAs, such as microRNAs (miRNAs) and long ncRNAs (lncRNAs), to facilitate carcinogenesis. Elucidating the mechanisms of HPV-ncRNA interactions will allow the critical role of ncRNAs in virus-host dynamics to be better understood, possibly allowing ncRNAs to be used as biomarkers for early cancer detection.
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