Related Experiment Video
Updated: Sep 17, 2025

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
Published on: July 7, 2016
Effectiveness of Pharmacist Interventions in Improving Medication Use in Hospitalised Older Patients Diagnosed With
Romana Santos Gama1, Luiz Carlos Passos2, Welma Wildes Amorim3
1Postgraduate Program in Pharmaceutical Services and Policies, Federal University of Bahia, Salvador, Bahia, Brazil.
Objectives:
This study aimed to assess the effectiveness of pharmacist interventions to reduce the omission of evidence-based cardiovascular medication, as well as polypharmacy and promote the deprescribing of potentially inappropriate medications in hospitalised older patients diagnosed with cardiovascular diseases.
Methods:
This before-and-after study was conducted among patients aged ≥ 60 years (n = 319) at a cardiovascular hospital in Brazil. Pharmacists conducted medication reviews for these patients. The first prescription on hospital admission and that at discharge were collected and compared for prescribing omission, polypharmacy, and prescribing of potentially inappropriate medications.
Results:
The mean patient age was 68.9 (±6.2) years. The mean incidences of prescribing potentially inappropriate medications and omissions decreased from 0.90 at admission to 0.10 at discharge (p < 0.001) and from 0.65 to 0.30 (p < 0.001), respectively. The number of potentially inappropriate medications prescribed decreased significantly, from 291 at admission to 28 at discharge, reflecting a 90% reduction. Additionally, the mean number of medications prescribed decreased from 9.8 to 6.5 (p < 0.001).
Conclusion:
This study emphasises the role of medication reviews by clinical pharmacists in reducing polypharmacy, prescribing omissions, and inappropriate prescribing in older adults with cardiovascular diseases, demonstrating that targeted pharmacist interventions improve medication safety.
Trial Registration:
Registered on ClinicalTrials.gov (NCT04800900).
More Related Videos
05:41Left Anterior Descending Coronary Artery Ligation for Ischemia-Reperfusion Research: Model Improvement via Technical Modifications and Quality Control
Published on: December 16, 2022
14:35Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
Related Concept Videos
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Cardiomyopathy V: Interprofessional Care
Heart Failure VII: Nursing Interventions
Coronary Artery Disease V: Interprofessional Care
Heart Failure V: Medical Management
Peripheral Artery Disease III: Interprofessional Care