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Grade III Varicocele Surgical Treatment using Spermatic Vein-Superficial Abdominal Vein Shunt

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Sperm DNA Fragmentation in Men with Varicocele: A Systematic Review and Meta-Analysis.

Ayad Palani^1,2, Selahittin Çayan^2,3, Rossella Cannarella^2,4,5

¹Department of Basic Sciences, College of Medicine, University of Garmian, Kalar, Iraq.

The World Journal of Men'S Health

|June 29, 2025

Summary

Varicocele significantly increases sperm DNA fragmentation (SDF), negatively impacting male fertility. SDF analysis can help clinicians decide on varicocele repair for affected patients.

Keywords:

DNA fragmentation Infertility, male Spermatozoa Varicocele

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Combined Supine and Standing Imaging for Varicocele: An Improved Diagnostic Approach

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Published on: November 22, 2024

Area of Science:

Reproductive Medicine
Andrology
Genetics

Background:

Varicocele is a common cause of male infertility.
Sperm DNA fragmentation (SDF) is increasingly recognized as a factor in male reproductive health.

Purpose of the Study:

To systematically review and meta-analyze the relationship between varicocele and SDF.
To compare SDF and conventional semen parameters in men with and without varicocele.

Main Methods:

Systematic search of Scopus and PubMed databases for relevant observational studies.
Inclusion of studies comparing SDF and semen parameters in men with varicocele versus controls.
Quantitative synthesis of data from 35 included studies.

Main Results:

Men with varicocele exhibited significantly higher SDF compared to controls (MD 15.34).
Varicocele was associated with reduced sperm concentration, total sperm count, vitality, and motility.
Normal sperm morphology was decreased, while abnormal forms increased in men with varicocele.

Conclusions:

Varicocele adversely affects male fertility through increased SDF.
SDF assessment is valuable for clinical decision-making regarding varicocele repair.