Related Experiment Video
Updated: Sep 17, 2025

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
The Distribution of HLA-DRB4 Alleles Among HLA-DRB1*07:01-Positive Haplotypes in Saudi Arabia
Sheerin A Alandejani1, Fatma Aytül Uyar2, Abdullah Alrasheed1
1Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City-Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Abstract:
This study investigates the distribution of human leukocyte antigen (HLA)-DRB4 alleles in HLA-DRB1*07:01-positive haplotypes within a Saudi cohort of 313 individuals. It identifies strong linkage disequilibrium between HLA-DRB1*07:01 and specific alleles. The most prevalent HLA-DRB1∼DQB1 combination identified is DRB1*07:01∼DQB1*02:02. Additionally, for the HLA-DRB1*07:01∼DQB1*03:03 association, DRB4*01:01 was found to be more common than the DRB4*01:03N allele. The most frequently observed extended haplotype is HLA-A*02:01∼C*06:02∼B*50:01∼DRB1*07:01∼DRB4*01:03∼DQA1*02:01∼DQB1*02:02∼DPA1*01:03∼DPB1*04:01. These findings emphasize the distinct genetic characteristics of the Saudi population and contribute to understanding haplotypic diversity, particularly the prevalence of HLA-DR7-related alleles and their implications for disease susceptibility and transplantation compatibility.
More Related Videos
07:26High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
Published on: July 18, 2017
08:51Genotyping of Staphylococcus aureus by Ribosomal Spacer PCR RS-PCR
Published on: November 4, 2016
Related Concept Videos
Blood Types
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
Multiple Allele Traits
Rh Blood Group
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Blood Typing
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...