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Published on: May 31, 2024
Total synthesis and algaecidal activity of questiomycins against harmful bloom forming dinoflagellates
Shuxin Yang1, Niraj Aryal2, Siti Nur Qamarina Binti Azmi1
1School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia. sjwill@unimelb.edu.au.
Abstract:
We report the total synthesis of questiomycins A, C-E and analogues, and their algaecidal activity against three harmful bloom- and toxin-forming algae: Karenia brevis, Prorocentrum cordatum, and Amphidinium carterae. Structure-activity relationship studies revealed potent derivatives with distinct modes of action, signalling their potential as targeted agents for harmful algal bloom control.
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