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[Analysis of nutritional status before and after different induction therapies in children with Crohn's disease]

Lei-Lei Chen1, Yu Yu1, You-You Luo1

  • 1Department of Gastroenterology, Children's Hospital, Zhejiang University School of Medicine/National Clinical Research Center for Child Health, Hangzhou 310052, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|June 30, 2025
PubMed

Insights

Exclusive enteral nutrition (EEN), corticosteroids, and infliximab (IFX) improved weight and hemoglobin in pediatric Crohn's disease (CD). EEN and IFX showed greater benefits for specific nutrients compared to corticosteroids.

Area of Science:

  • Pediatric gastroenterology
  • Nutritional science
  • Immunology

Context:

  • Crohn's disease (CD) is a chronic inflammatory bowel disease affecting children.
  • Nutritional status is a critical concern in pediatric CD management.
  • Induction remission therapies aim to reduce inflammation and improve clinical outcomes.

Purpose:

  • To evaluate the impact of exclusive enteral nutrition (EEN), corticosteroids, and infliximab (IFX) on the nutritional status of pediatric patients with Crohn's disease.
  • To compare the efficacy of these three induction remission therapies in improving anthropometric and biochemical markers.

Summary:

  • A retrospective analysis of 188 children with CD compared EEN, corticosteroids, and IFX.
  • All therapies improved weight-for-age Z scores, hemoglobin, and albumin (P<0.05).
  • EEN and IFX demonstrated superior improvements in 25-hydroxy vitamin D, folic acid, serum iron, and total calcium compared to corticosteroids (P<0.05).

Impact:

  • Findings suggest that EEN, corticosteroids, and IFX can effectively enhance nutritional status in children with CD.
  • Exclusive enteral nutrition and infliximab may offer advantages over corticosteroids for specific micronutrient repletion.
  • This research informs therapeutic strategies for optimizing nutritional outcomes in pediatric Crohn's disease.
Abstract

Keywords:
ChildCrohn's diseaseInduction remissionNutrition

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