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Theranostic Toolbox for Neutrophil Functionalization.

Pascal Bouvain1, Kay-Matthias Thomy1, Anika Maria Prinz2

  • 1Experimental Cardiovascular Imaging, Molecular Cardiology, Heinrich Heine University, 40225, Düsseldorf, Germany.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|June 30, 2025
PubMed
Summary
This summary is machine-generated.

This study developed nanoparticle tools to control neutrophil functions for treating inflammation. These nanotheranostics can target neutrophils to enhance healing or reduce damage, improving disease outcomes.

Keywords:
MRIfluorineinflammationneutrophilstargeted nanoparticlestheranostics

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Area of Science:

  • Immunology
  • Nanotechnology
  • Medical Imaging

Background:

  • Neutrophils are vital immune cells for pathogen defense and wound healing.
  • Dysregulated neutrophil activity can exacerbate inflammation and tissue damage.
  • Targeted modulation of neutrophil function is needed for effective disease management.

Purpose of the Study:

  • To engineer a nanoparticle-based toolbox for directing neutrophil phenotypes.
  • To develop a theranostic approach for monitoring and modulating neutrophil functions.
  • To tailor neutrophil responses for specific inflammatory conditions.

Main Methods:

  • Development of neutrophil-specific fluorine nanoparticles with peptide modifications.
  • Utilizing 19F MRI for background-free in vivo monitoring.
  • Testing modulation of effector functions in murine and human neutrophils.
  • Application in a mouse model of bacteria-driven acute colitis.

Main Results:

  • Demonstrated specific modulation of neutrophil effector functions.
  • Enabled non-invasive in vivo monitoring of neutrophil infiltration.
  • Showed attenuation or amplification of neutrophil functions in disease models.
  • Successfully ameliorated tissue damage in acute colitis.

Conclusions:

  • The engineered nanotheranostic approach allows visualization and control of neutrophil functionality.
  • This technology can be tailored to specific inflammatory environments.
  • It offers a promising strategy for personalized neutrophil immunotherapy to improve disease outcomes.