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Updated: Sep 17, 2025

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
Correlation Between Lipid Accumulation Product and Metabolic Dysfunction-Associated Steatotic Liver Disease in
Wei Liu1, Lingling Xu1, Yuan Yu2
1Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210028, People's Republic of China.
Objective:
To evaluate the value and feasibility of the lipid accumulation product (LAP) in the prediction of metabolic dysfunction-associated steatotic liver disease (MASLD) in Chinese adults with type 2 diabetes mellitus (T2DM).
Methods:
In this cross-sectional study, we assessed the value of LAP and other novel indices in the prediction of MASLD in Chinese adults with T2DM in a total of 642 patients. Receiver Operating Characteristic (ROC) curves were plotted to assess the predictive ability of the indices for the occurrence of MASLD in T2DM.
Results:
The results showed that LAP had a strong predictive ability for the occurrence of MASLD in T2DM in both men and women and was superior to other traditional visceral fat-related indices. In men, the area under curve (AUC) (95% CI) was 0.815 (0.771-0.859) with cut-off value of 36.01, and its sensitivity and specificity were 71.91% and 77.44%, respectively. And in women, the AUC (95% CI) was 0.816 (0.762-0.870) with cut-off value of 24.22, and its sensitivity and specificity were 84.93% and 63.54%, respectively.
Conclusion:
LAP has a high predictive ability for the occurrence of MASLD in T2DM in both men and women and are superior to other traditional visceral fat-related indices.
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