The longitudinal impact of screen media activities on brain function, architecture and mental health in early...

The increased use of screen media has raised unknown effects on mental health among adolescents. This study aimed to examine the correlational and causal association between screen media activity (SMA) and mental health problems, and the mediating role of brain functions and structures in this relationship. Data from 4557 adolescents (mean age = 9.955 ± 0.164 years) in the Adolescent Brain Cognitive Development (ABCD) study were analysed across four time points: baseline, 1-year, 2-year, and 3-year follow-ups. Linear mixed models assessed SMA's association with mental health indices and the brain's developmental pattern, respectively. Cross-lagged panel models examined the SMA-mental health problems' longitudinal and causal relationship. Mediation analyses explored brain functions and structures as mediators on the SMA-mental health correlation. Baseline SMA positively correlated with internalizing, externalizing, and stress problems; and negatively correlated with brain volume, area and diverse sets of resting-state functional connectivity (RSFC) after three years. Higher baseline SMA associated with increased internalizing (β = 0.030, SE= 0.012, p_fdr = 0.016), and stress problems (β = 0.026, SE = 0.012, p_fdr = 0.037) three years later. The RSFC between the cingulo-opercular network (CON) and the retrosplenial temporal network (RTN) mediated the effects of SMA on externalizing (β = 0.002, p_fdr = 0.042) and stress problems (β = -0.003, p_fdr = 0.022). TV watching predicted higher externalizing problems (β = 0.054, pfdr < 0.001), while video watching predicted increased internalizing (β = 0.061, pfdr < 0.001), externalizing (β = 0.033, pfdr = 0.035), and stress problems (β = 0.060, pfdr < 0.001). The findings indicate the negative impact of SMA, particularly TV and video watching, on adolescent mental health, mediated by changes in CON and RTN functional connectivity. Future research can explore the specific risks associated with video streaming and consider the role of emerging technologies such as virtual reality in SMA on adolescent mental health.