Inclusion of Vitamin E in 1D Nanochannels of 2,4,6-Tris(4-chlorophenoxy)-1,3,5-triazine: Structural and Thermal...

Vitamin E (VE; (±)-α-tocopherol) is a potent antioxidant that plays a critical role in protecting cells from oxidative stress. However, its effectiveness is hindered by its susceptibility to oxidation during storage and poor absorption in the digestive system. Conventional stabilization methods often rely on chemical modifications or the excessive use of excipients, which can reduce VE's effectiveness. Therefore, a delivery system capable of preserving the antioxidant properties of VE without altering its chemical structure is essential. In this study, we develop an inclusion compound in which VE is encapsulated within the 1D nanochannels of 2,4,6-tris-(4-chlorophenoxy)-1,3,5-triazine (CLPOT), forming [(CLPOT)₂-(VE)_0.49]. These nanochannels physically isolate VE from environmental oxidizing agents to prevent oxidation. In addition, structural and thermal analyses, including powder and single-crystal X-ray diffraction, thermogravimetry-differential thermal analysis, and solution (¹H or ¹³C) and solid-state (¹³C) nuclear magnetic resonance, confirm stable incorporation of VE into the CLPOT nanochannels consisting of periodical hexagonal CLPOT crystals without requiring chemical modification. Compared with conventional encapsulation techniques, this method provides enhanced protection by creating a confined and protective environment. These findings suggest that CLPOT-based systems offer a promising platform for stabilizing and delivering fat-soluble nutrients, such as VE.