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Small Nucleolar RNAs: Biological Functions and Diseases.
Yi Wang1,2, Min Fu3, Zaiyong Zheng4
1Department of Anesthesiology The Affiliated Hospital Southwest Medical University Luzhou Sichuan Province China.
Medcomm
|June 30, 2025
Summary
Small nucleolar RNAs (snoRNAs) are key regulators of cellular processes and RNA modifications. Their dysregulation is linked to diseases like cancer, highlighting their biomarker potential.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- Small nucleolar RNAs (snoRNAs) are critical non-coding RNAs involved in cellular functions.
- These molecules guide RNA modifications and are implicated in numerous human diseases.
Purpose of the Study:
- To provide a comprehensive overview of snoRNA classification, biogenesis, and functions.
- To explore the role of snoRNAs in health and disease, and their potential as biomarkers.
Main Methods:
- Literature review and synthesis of current research on snoRNAs.
- Discussion of advancements in high-throughput sequencing, structural biology, and bioinformatics.
Main Results:
- SnoRNAs have canonical roles in RNA modification and ribosome biogenesis.
- Noncanonical functions include mRNA processing, alternative splicing, and lncRNA interactions.
- SnoRNA dysregulation is associated with cancer, neurodegenerative disorders, and aging.
Conclusions:
- SnoRNAs are crucial players in cellular processes and disease pathogenesis.
- Despite technological advances, challenges remain in understanding snoRNA complexity and clinical translation.
Keywords:
cancercardiovascular diseasesneurological diseasesnucleic acid‐based drugssmall nucleolar RNAsMore Related Videos
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