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Bibliometric and visualization analysis of glioma pharmacotherapy from 2020 to 2024
Xinjie Hong1, Zhentao Wei1,2, Tian Zuo1
1Department of Neurosurgery, The Second Affiliated Hospital of Naval Medical University, Shanghai, China.
Objective:
Gliomas are the most common and aggressive malignant tumors of the central nervous system. Their complex biology and adaptive resistance mechanisms pose major obstacles to existing treatment strategies. This study aims to analyze research published over the past 5 years to identify emerging trends, effective therapeutic agents, and novel treatment strategies.
Methods:
Relevant articles on glioma drug therapy were retrieved from the Web of Science Core Collection for the period 2020-2024. Bibliometric analyses were performed using CiteSpace and VOSviewer to examine authorship, institutional and national contributions, journal impact, and keyword distributions. A total of 9,701 articles were included in the analysis.
Results:
China leads in publication volume on glioma research, followed by the United States. Liu Yang from China is the most prolific author in this field over the past 5 years. Institutions from China and the United States are the primary contributors to this area of research. Bibliometric analysis identified four major thematic clusters: glioma treatment, drug delivery, immunotherapy and the tumor microenvironment, and the molecular mechanisms underlying glioma cell behavior.
Conclusion:
This systematic analysis of glioma treatment research over the past 5 years highlights key global research hotspots and emerging trends. Drug delivery and immunotherapy have gained increasing attention as promising therapeutic approaches. Advances in glioma treatment are expected to improve patient outcomes.
Insights
Recent glioma research highlights China
Area of Science:
- Neuro-oncology
- Cancer Research
- Bibliometrics
Background:
- Gliomas are aggressive central nervous system tumors.
- Treatment resistance presents significant challenges.
- Understanding research trends is crucial for advancing therapies.
Purpose of the Study:
- Analyze 5-year research trends in glioma.
- Identify emerging therapeutic agents and strategies.
- Map global research contributions and hotspots.
Main Methods:
- Bibliometric analysis of 9,701 articles (2020-2024).
- Utilized CiteSpace and VOSviewer for data analysis.
- Examined authorship, institutions, nations, and keywords.
Main Results:
- China leads in glioma research publications.
- Key research clusters include drug delivery and immunotherapy.
- Tumor microenvironment and molecular mechanisms are also prominent.
Conclusions:
- Drug delivery and immunotherapy are emerging as key glioma treatment areas.
- Global research collaboration is evident.
- These trends may lead to improved patient outcomes.
