Related Experiment Video
Updated: Sep 17, 2025
A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva
Published on: January 12, 2019
Nailfold Video Capillaroscopy in Acute and Chronic Skin Graft Versus Host Disease
Sehreen Mumtaz1, Florentina Berianu1, Puneet Bhullar2
1Department of Rheumatology, Mayo Clinic, Jacksonville, FL.
Objective:
To assess the utility of nailfold video capillaroscopy (NVC) in patients diagnosed with acute and chronic graft versus host disease (GVHD) of the skin.
Patients And Methods:
Patients diagnosed with acute and chronic skin GVHD (n=11) and those without the diagnosis of GVHD (controls) (n=21) underwent NVC to assess capillary density, morphology, and hemorrhage. Statistical comparisons were made using Fisher's exact test. The study was performed from March 1, 2024, to August 1, 2024.
Results:
Patients diagnosed with acute and chronic GVHD were observed to have considerably more microhemorrhages, ramifications, and disorganized capillaries when compared with patients without a diagnosis of acute or chronic GVHD.
Conclusion:
This study reveals significant NVC abnormalities in patients with GVHD, suggesting distinct microvascular features that imply potential diagnostic value. The NVC may be a valuable tool for diagnosing and monitoring GVHD and warrants further investigation in larger cohorts.
