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Updated: Sep 17, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.4K

Deciphering the multifaceted role of circular RNA in aging: from molecular mechanisms to therapeutic potentials

Yang Wang1,2, Cong Wang1,2, Xin Dai1,2

  • 1School of Graduate, Shaanxi University of Chinese Medicine, No. 1 Middle Section of Shiji Avenue, Xianyang 712046, China.

Non-Coding RNA Research
|June 30, 2025
PubMed

Insights

Circular RNAs (circRNAs) are key molecules regulating aging processes. Understanding circRNA functions offers strategies to delay aging and manage age-related diseases.

Area of Science:

  • Molecular Biology
  • Genetics
  • Gerontology

Background:

  • Aging is a natural process where organ function declines, increasing disease risk.
  • Extending lifespan necessitates strategies to mitigate aging's effects.
  • Circular RNAs (circRNAs) are novel non-coding RNAs with significant biological roles.

Purpose of the Study:

  • To investigate the mechanisms of circRNA-mediated gene regulation in aging.
  • To explore circRNA's role in epigenetic modifications and cellular functions.
  • To assess the therapeutic potential of circRNAs in aging-associated disorders.

Main Methods:

  • Literature review on circRNA biogenesis and function.
  • Analysis of circRNA involvement in cellular senescence pathways.
  • Exploration of circRNA as miRNA sponges and regulators of gene expression.

Main Results:

  • CircRNAs regulate gene expression through various mechanisms, including miRNA sponging.
  • These molecules influence epigenetic modifications and cellular senescence.
  • CircRNAs are implicated in critical cellular processes like cell cycle, apoptosis, and autophagy.

Conclusions:

  • CircRNAs are crucial regulators of aging processes at the molecular level.
  • Targeting circRNAs may offer novel therapeutic strategies for aging and related diseases.
  • Further research into circRNA functions is essential for developing anti-aging interventions.
Keywords:
AgingBiomarkersCell cycleCircRNAGene expression regulation

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