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Revolutionizing neural regeneration with smart responsive materials: Current insights and future prospects
Hongxia Gao1, Huoyun Shen1, Xunrui Zhang2
1Key Laboratory of Neuroregeneration, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.
Bioactive Materials
|June 30, 2025
Summary
Smart-responsive materials (SRM) offer advanced solutions for neural regeneration, aiding in drug delivery and tissue repair. This review details SRM advancements, applications, and future trends in nerve injury treatment.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Neuroscience
Background:
- Smart-responsive materials (SRM) are crucial for advanced tissue engineering.
- SRM enable dynamic environmental interaction for novel therapeutic systems.
- Significant potential exists for SRM in neural regeneration applications.
Purpose of the Study:
- To comprehensively review smart-responsive materials for neural regeneration.
- To summarize SRM response mechanisms, classifications, and applications.
- To provide a reference for researchers in neural tissue engineering.
Main Methods:
- Systematic review of current literature on SRM.
- Analysis of SRM response mechanisms and classifications.
- Evaluation of SRM applications in peripheral nerve, spinal cord, and brain injury.
Main Results:
- SRM development has progressed through multiple generations.
- Diverse SRM are utilized for drug delivery, graft fabrication, and detection in neural regeneration.
- Limitations of current SRM in neural regeneration were identified.
Conclusions:
- SRM are pivotal in advancing neural regeneration therapies.
- Further development of novel SRM is emphasized for improved outcomes.
- SRM hold significant promise for future nerve regeneration strategies.
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