Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lens changes and survival in a population-based study.

M J Podgor, G H Cassel, W B Kannel

    The New England Journal of Medicine
    |December 5, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Efficiency robust tests for survival or ordered categorical data.

    Biometrics·2001
    Same author

    High intraocular pressure and survival: the Framingham Studies.

    American journal of ophthalmology·1999
    Same author

    G-estimation of causal effects: isolated systolic hypertension and cardiovascular death in the Framingham Heart Study.

    American journal of epidemiology·1998
    Same author

    Sudden coronary death in women.

    American heart journal·1998
    Same author

    A longitudinal study of body mass index and lens opacities. The Framingham Studies.

    Ophthalmology·1998
    Same author

    Effects of fenretinide (4-HPR) on dark adaptation.

    Archives of ophthalmology (Chicago, Ill. : 1960)·1998
    Same journal

    Ebola at 50 - Lessons for Outbreak Response and Preparedness.

    The New England journal of medicine·2026
    Same journal

    Ianalumab plus Eltrombopag in Immune Thrombocytopenia. Reply.

    The New England journal of medicine·2026
    Same journal

    Ianalumab plus Eltrombopag in Immune Thrombocytopenia.

    The New England journal of medicine·2026
    Same journal

    Hypertension Control in Low-Income Patients. Reply.

    The New England journal of medicine·2026
    Same journal

    Hypertension Control in Low-Income Patients.

    The New England journal of medicine·2026
    Same journal

    Hypertension Control in Low-Income Patients.

    The New England journal of medicine·2026
    See all related articles

    Lens changes predict survival in individuals with diabetes. This study found that lens changes were associated with decreased survival in diabetic patients, but not in non-diabetic individuals.

    Area of Science:

    • Ophthalmology
    • Cardiovascular Disease Epidemiology
    • Diabetology

    Background:

    • The Framingham Heart Study, initiated in 1948, investigates cardiovascular disease risk factors.
    • The Framingham Eye Study (1973-1975) examined ocular health in Heart Study participants.
    • Lens changes are a common ocular finding, particularly in aging populations.

    Purpose of the Study:

    • To investigate the relationship between lens changes and survival rates.
    • To determine if lens changes are associated with mortality in a population-based cohort.
    • To explore differential associations between lens changes and survival in diabetic versus non-diabetic individuals.

    Main Methods:

    • Utilized data from nearly 2000 participants from the Framingham Heart and Eye Studies.

    Related Experiment Videos

  • Employed proportional-hazards regression analyses to assess survival.
  • Follow-up duration ranged from five to eight years, with 312 deaths recorded.

    • Main Results:

    • An overall association between lens changes and decreased survival was observed (P = 0.01).
    • No significant association was found between lens changes and survival in individuals without diabetes (P = 0.29).
    • A significant association between lens changes and decreased survival was identified in individuals with diabetes (P = 0.001), with a more than twofold increased death rate.

    Conclusions:

    • Lens changes are significant predictors of mortality in diabetic individuals.
    • Lens changes may serve as earlier indicators of mortality risk in diabetes compared to traditional variables like diabetes duration or retinopathy.
    • Ocular health, specifically lens status, warrants consideration in assessing prognosis for diabetic patients.