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Updated: Sep 17, 2025
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Repeated corneal crosslinking for progressive keratoconus: efficiency and safety
Eleftherios Chatzimichail1, Georgios Chondrozoumakis2, Farideh Doroodgar3
1Department of Ophthalmology, University Hospital of Basel, Basel, Switzerland.
Abstract:
Corneal crosslinking (CXL) was first introduced in clinical practice in 2003. Since then, this procedure has been established as the first-line treatment in the management of progressive keratoconus. Over the last years, many different protocols have emerged, each one of them with variable clinical outcomes and safety profile. Progression of keratoconus after primary CXL is very rare, but it has been reported in the literature. This review summarises the existing data on repeated CXL after primary failure, emphasising on clinical efficacy and safety.
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