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Updated: Sep 17, 2025
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Repeated corneal crosslinking for progressive keratoconus: efficiency and safety
Eleftherios Chatzimichail1, Georgios Chondrozoumakis2, Farideh Doroodgar3
1Department of Ophthalmology, University Hospital of Basel, Basel, Switzerland.
Repeated corneal crosslinking (CXL) offers a viable option for progressive keratoconus cases that do not respond to initial treatment. This review examines the effectiveness and safety of repeat CXL procedures.
Area of Science:
- Ophthalmology
- Corneal Surgery
Background:
- Corneal crosslinking (CXL) is a standard treatment for progressive keratoconus.
- While effective, some cases show progression after the initial CXL procedure.
Purpose of the Study:
- To review the clinical efficacy and safety of repeat corneal crosslinking (CXL) in managing progressive keratoconus.
- To summarize existing data on repeated CXL following primary treatment failure.
Main Methods:
- Literature review of studies reporting on repeated corneal crosslinking (CXL) for progressive keratoconus.
- Analysis of clinical outcomes and safety profiles from existing data.
Main Results:
- Progression of keratoconus after primary CXL is uncommon but documented.
- Existing data on repeated CXL for primary failure is summarized, highlighting variable outcomes and safety.
Conclusions:
- Repeated corneal crosslinking (CXL) is a potential retreatment option for progressive keratoconus.
- Further research is needed to fully establish optimal protocols and long-term outcomes for repeat CXL.
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