Proliferating Giant Pilomatrixoma: A Case Report

Area of Science:

• Dermatology
• Pathology
• Oncology

Background:

• Pilomatrixoma is a benign skin tumor originating from the hair follicle matrix.
• It commonly affects pediatric and young adult populations.
• Clinicopathological variants exist, including giant pilomatrixoma (≥4 cm).

Observation:

• A 36-year-old female presented with a rapidly growing exophytic mass on her right cheek after trauma.
• The mass raised suspicion for malignancy due to its size and rapid growth.
• Histopathological examination revealed a proliferating pilomatrixoma.

Findings:

• The case presented a giant pilomatrixoma, defined by its size (≥4 cm).
• The histological subtype was identified as proliferating pilomatrixoma.
• The tumor mimicked malignant neoplasms like angiosarcoma or amelanotic melanoma.

Implications:

• Giant and proliferating pilomatrixoma variants require careful diagnosis to differentiate from malignant tumors.
• Complete surgical excision is crucial for managing giant pilomatrixoma.
• Incomplete excision can lead to local recurrence and potential malignant transformation.