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Cardiovascular Risk Among Patients With Moderate-to-Severe Plaque Psoriasis in Southern Sri Lanka: A Case-Control
Achala Liyanage1, Gayani Liyanage2, Binari Wijenayake3
1Dermatology, Faculty of Medicine, University of Ruhuna, Galle, LKA.
Cureus
|June 30, 2025
Summary
Patients with chronic plaque psoriasis have increased comorbidities and unadjusted lipid levels, indicating a need for comprehensive patient evaluation. Healthcare professionals should adopt a holistic approach for managing psoriasis patients.
Area of Science:
- Dermatology
- Cardiovascular Medicine
- Public Health
Background:
- Psoriasis is a chronic inflammatory skin disease linked to elevated cardiovascular risk and comorbidities.
- Understanding these associated risks is crucial for patient management.
Purpose of the Study:
- To evaluate cardiovascular risk and contributing factors in patients with chronic plaque psoriasis (CPP).
- To compare cardiovascular risk profiles between CPP patients and a matched control group.
Main Methods:
- A case-control study involving 80 patients with CPP and 80 controls in Southern Sri Lanka.
- Data collected via questionnaires, anthropometric measurements, and biochemical assays (blood glucose, lipids).
- Cardiovascular risk assessed using Framingham Risk Score (FRS) and Atherosclerotic Cardiovascular Disease (ASCVD) 10-year risk score; comorbidity by Charlson Comorbidity Index (CCI).
Main Results:
- Psoriasis patients exhibited higher CCI scores and a greater prevalence of dyslipidemia compared to controls.
- Elevated triglycerides and TG/HDL ratios were observed in CPP patients.
- While cardiovascular risk scores were higher in the psoriasis group, the difference was not statistically significant.
Conclusions:
- Patients with CPP demonstrate increased comorbidity and unadjusted lipid abnormalities.
- Emphasizes the necessity for healthcare professionals to implement a holistic evaluation strategy for CPP patients.
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