A Case of Spinal Epidural Extramedullary Hematopoiesis Diagnosed Using Indium-111 Bone Marrow Scintigraphy

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Haruka Tanaka1, Masashi Nakadate1, Hiroyuki Inose2

  • 1Department of Radiology, Dokkyo Medical University Saitama Medical Center, Saitama, JPN.

Cureus
|June 30, 2025
PubMed

Although indium-111 (111In) bone marrow scintigraphy is commonly used to assess bone marrow function, it plays a significant role in diagnosing extramedullary hematopoiesis (EMH) due to isotope accumulation in hematopoietic bone marrow. In our case, a 67-year-old man with polycythemia vera presented with an epidural tumor, for which EMH was considered a differential diagnosis. The diagnosis was subsequently confirmed by 111In bone marrow scintigraphy. The tumors exhibited a reduction in size following radiation therapy. We report this case to highlight the utility of 111In bone marrow scintigraphy in diagnosing EMH. This imaging modality can confirm epidural EMH and help avoid unnecessary surgeries.

Keywords:
extramedullary hematopoiesisin-111 bone marrow scintigraphynuclear medicineradiotherapyspinal epidural tumor

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