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Inflammatory Bowel Disease Induces Colorectal Cancer: Risk Factors, Triggering Mechanisms, and Treatment With
Yuyu Zhang1, Yi Zhang1, Shiyi Yao2
1College of Food and Bioengineering, Xihua University, Chengdu, China.
Phytotherapy Research : PTR
|June 30, 2025
Summary
Phyto-derivatives show promise in preventing colitis-associated colon cancer (CAC), a serious condition linked to inflammatory bowel disease (IBD). Further research into these plant-derived compounds could lead to new strategies for inhibiting intestinal inflammation and preventing cancer development.
Area of Science:
- Oncology
- Gastroenterology
- Pharmacology
Background:
- Colorectal cancer (CRC) is a major global health concern, with colitis-associated colon cancer (CAC) being an aggressive subtype.
- Patients with chronic inflammatory bowel disease (IBD) face an elevated risk of developing CAC.
- The complex pathogenesis of CAC, driven by chronic intestinal inflammation, currently lacks standardized preventive strategies.
Purpose of the Study:
- To comprehensively analyze predisposing factors and pathogenesis of CAC.
- To elucidate the mechanisms by which plant-derived compounds inhibit CAC development.
- To explore innovative strategies for CAC prevention using natural products.
Main Methods:
- Review of existing literature on CAC pathogenesis and risk factors.
- Analysis of studies on the anti-inflammatory, antioxidant, and gut microbiota-regulating properties of plant-derived compounds.
- Examination of mechanisms underlying the chemopreventive effects of phyto-derivatives.
Main Results:
- Phyto-derivatives, including polyphenols, alkaloids, saponins, terpenoids, polysaccharides, and plant extracellular vesicles, demonstrate significant potential in preventing CAC.
- These natural compounds exert anti-inflammatory, antioxidant, and gut microbiota-modulating effects.
- Plant-derived compounds offer a promising avenue for inhibiting the progression of chronic intestinal inflammation to malignancy.
Conclusions:
- Natural products hold significant potential for the advance prophylaxis of CAC.
- Targeting chronic intestinal inflammation with plant-derived compounds is a viable strategy to prevent CAC development.
- This review provides a foundation for developing novel, practical approaches to CAC prevention.
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