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Updated: Sep 20, 2026

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay
10:12

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay

Published on: August 8, 2013

[Creatine kinase BB activity in the serum of patients with cerebrovascular diseases]

R Kloss, H E Keller, T Stober

    Der Nervenarzt
    |August 1, 1985
    PubMed

    Insights

    Serum creatine kinase BB isoenzyme (CK-BB) levels increase significantly with the severity of cerebrovascular disease lesions. Severe lesions showed peak CK-BB activity on day one post-symptoms, indicating its potential as a biomarker.

    Area of Science:

    • Biochemistry
    • Neurology
    • Medical Diagnostics

    Context:

    • Conflicting reports exist regarding creatine kinase BB isoenzyme (CK-BB) activity in cerebrovascular disease.
    • Accurate assessment of CK-BB levels is crucial for understanding its role in neurological conditions.

    Purpose:

    • To investigate the correlation between serum CK-BB activity and the extent of brain lesions in patients with cerebrovascular disease.
    • To clarify the diagnostic utility of CK-BB in differentiating lesion severity.

    Summary:

    • Serum CK-BB activity was measured in 33 patients with ischemic brain infarction, subarachnoid hemorrhage, or intracerebral hemorrhage using a bioluminescence method and immunoprecipitation.
    • A significant elevation in CK-BB activity was observed in patients with more extensive and severe brain lesions compared to controls.
    • Patients with severe lesions exhibited peak CK-BB activity on the first day following symptom onset.

    Impact:

    • This study provides evidence that elevated serum CK-BB levels are associated with the severity of cerebrovascular lesions.
    • Findings suggest CK-BB may serve as a valuable biomarker for assessing the extent of brain damage in cerebrovascular events.
    • The temporal profile of CK-BB elevation, particularly its peak on day one in severe cases, offers insights for clinical monitoring.

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