Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

2.4K
Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can...
2.4K
Fibril-associated Collagen01:11

Fibril-associated Collagen

2.7K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of visual outcomes of phakic intraocular lens implantation in keratoconus and normal eyes.

International ophthalmology·2026
Same author

Progressive inferior keratoconus in a patient misdiagnosed as pellucid marginal corneal degeneration.

BMJ case reports·2026
Same author

Oxidative Stress in Keratoconus Is Evident in Tear Fluid and Stromal Cells and Alleviated in Cell Culture by Sulforaphane.

Investigative ophthalmology & visual science·2026
Same author

Corneal transplantation triple procedures.

Survey of ophthalmology·2026
Same author

Oxidative-stress related increase in keratoconus tear MDA and GPX3 while NRF2-antioxidant functions decrease in stromal cells.

bioRxiv : the preprint server for biology·2025
Same author

Editorial: Reviews in: ophthalmology 2024.

Frontiers in medicine·2025

Related Experiment Video

Updated: Sep 17, 2025

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

20.0K

Collagen crosslinking in thin corneas.

Aniruddh Heroor1, Rashmi Deshmukh

  • 1Cataract and Refractive Services, LV Prasad Eye Institute, Hyderabad, Telangana, India.

Indian Journal of Ophthalmology
|June 30, 2025
PubMed
Summary
This summary is machine-generated.

Corneal collagen cross-linking (CXL) halts keratoconus progression. Modified CXL techniques now enable treatment for thinner corneas, previously a limitation of the Dresden protocol.

Keywords:
Collagen crosslinkingkeratoconusthin cornea

More Related Videos

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia
12:25

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia

Published on: January 6, 2018

7.9K
Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

9.0K

Related Experiment Videos

Last Updated: Sep 17, 2025

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

20.0K
Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia
12:25

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking TXL for Myopia

Published on: January 6, 2018

7.9K
Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

9.0K

Area of Science:

  • Ophthalmology
  • Corneal Science

Background:

  • Collagen cross-linking (CXL) is the sole method to halt or slow keratoconus progression.
  • The standard Dresden protocol for CXL is contraindicated in corneas <400 µm due to endothelial damage risk.

Purpose of the Study:

  • To review the Dresden protocol parameters for CXL.
  • To identify limitations of conventional CXL in thin corneas.
  • To explore modifications enabling CXL in thinner corneas.

Main Methods:

  • Review of the Dresden protocol for corneal collagen cross-linking.
  • Analysis of safety and efficacy concerns in thin corneas.
  • Discussion of alternative CXL techniques.

Main Results:

  • Conventional CXL (Dresden protocol) poses risks to corneal endothelium in corneas <400 µm.
  • Various modifications to CXL protocols have been developed to address thin corneas.

Conclusions:

  • The Dresden protocol has limitations for thin corneas.
  • Modified CXL approaches offer solutions for treating keratoconus in thinner corneas.
  • This video explores current alternatives for CXL in thin corneas.