Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serum antioxidant activity in uremic patients.

M Kuroda, S Asaka, Y Tofuku

    Nephron
    |January 1, 1985
    PubMed
    Summary

    Serum antioxidant activity (AOA) is significantly lower in chronic renal failure (CRF) patients, especially those with uremic symptoms. Regular dialysis therapy (RDT) helps restore these levels, suggesting AOA defects contribute to uremic toxicity via lipid peroxidation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The results of radiotherapy for T1 glottic cancers; influence of radiation beam energy.

    Acta medica Okayama·1999
    Same author

    For the clinical application of thermochemotherapy given at mild temperatures.

    International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·1999
    Same author

    Chromosome-determined zinc-responsible operon czr in Staphylococcus aureus strain 912.

    Microbiology and immunology·1999
    Same author

    Influence of metabolic inhibitors on the intracellular accumulation and retention of adriamycin.

    Anticancer research·1999
    Same author

    Induction of a secreted protein by the myxoid liposarcoma oncogene.

    Proceedings of the National Academy of Sciences of the United States of America·1999
    Same author

    [Renal oncocytoma with cystic degeneration: a case report].

    Hinyokika kiyo. Acta urologica Japonica·1999

    Area of Science:

    • Biochemistry
    • Nephrology

    Background:

    • Chronic renal failure (CRF) is associated with metabolic disturbances.
    • Oxidative stress and lipid peroxidation are implicated in uremic toxicity.

    Purpose of the Study:

    • To investigate serum antioxidant activity (AOA) in patients with chronic renal failure (CRF).
    • To determine the relationship between AOA, malondialdehyde (MDA) levels, and the stage of renal failure.

    Main Methods:

    • Serum AOA was measured in 35 healthy subjects and 111 CRF patients (predialysis, starting RDT, undergoing RDT).
    • AOA was assessed by its ability to inhibit malondialdehyde (MDA) generation, a marker of lipid peroxidation.

    Main Results:

    • CRF patients exhibited significantly lower serum AOA compared to healthy controls.
    • The lowest AOA levels were observed in CRF patients with uremic symptoms requiring the initiation of regular dialysis therapy (RDT).
    • Serum AOA levels improved to subnormal levels during RDT and were inversely correlated with MDA levels.

    Conclusions:

    • Defective serum AOA is an endogenous consequence of uremia.
    • Low serum AOA in CRF patients increases susceptibility to cellular injury from lipid peroxidation.
    • Impaired serum AOA may contribute to uremic toxicity through peroxidative cell damage.

    Related Experiment Videos