Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

342
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
342
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

399
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
399
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

542
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
542
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

430
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
430
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.2K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.2K
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.7K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Practical dilemmas and communication reconstruction of patients' right to informed consent under the Civil Code.

Frontiers in public health·2026
Same author

A HRH1-YAP1 feedback loop drives pancreatic cancer progression and predicts therapeutic response.

Oncology letters·2026
Same author

Application and validation of a Fredformer framework for multi-indicator water quality forecasting in the Weihe River Basin.

Environmental monitoring and assessment·2026
Same author

Knowledge, Attitude, and Practice Toward Long-Term Anticoagulation in Patients with Venous Thromboembolism: A Cross-Sectional Study.

Patient preference and adherence·2026
Same author

Synergistic Effects of Air Pollutants and Extreme Temperature on Asthma: A Narrative Review of Mechanisms and Evidence.

Toxics·2026
Same author

Strategic optimization of osseous reconstruction for post-oncologic resection maxillofacial defects: a clinical outcomes analysis.

Journal of stomatology, oral and maxillofacial surgery·2026

Related Experiment Video

Updated: Sep 17, 2025

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
07:34

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

2.7K

CD131 contributes to ulcerative colitis pathogenesis by promoting macrophage infiltration.

Zhiyuan Wu1, Lindi Liu2, Chenchen He1

  • 1Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, China.

Elife
|June 30, 2025
PubMed
Summary

CD131 plays a role in ulcerative colitis (UC) pathogenesis by influencing immune responses and macrophage activity in the colon. This finding offers new insights into the mechanisms of GM-CSF and IL-3 in intestinal inflammation.

Keywords:
CD131Csf2rbT cellshumanimmunologyinflammationmacrophagemouseulcerative colitis

More Related Videos

Isolation and Characterization of Dendritic Cells and Macrophages from the Mouse Intestine
09:25

Isolation and Characterization of Dendritic Cells and Macrophages from the Mouse Intestine

Published on: May 21, 2012

39.3K
Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
06:57

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Published on: September 18, 2016

9.2K

Related Experiment Videos

Last Updated: Sep 17, 2025

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
07:34

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

2.7K
Isolation and Characterization of Dendritic Cells and Macrophages from the Mouse Intestine
09:25

Isolation and Characterization of Dendritic Cells and Macrophages from the Mouse Intestine

Published on: May 21, 2012

39.3K
Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
06:57

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Published on: September 18, 2016

9.2K

Area of Science:

  • Immunology
  • Gastroenterology

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unknown etiology.
  • CD131 is a receptor subunit for granulocyte-macrophage colony-stimulating factor (GM-CSF) and Interleukin-3 (IL-3), involved in inflammatory responses.
  • The role of CD131 in intestinal inflammation and UC pathogenesis requires further investigation.

Purpose of the Study:

  • To investigate the role of CD131 in the pathogenesis of ulcerative colitis.
  • To elucidate the mechanisms by which CD131 influences immune and inflammatory responses in the colon.

Main Methods:

  • A murine colitis model was established using dextran sulfate sodium (DSS).
  • Immune and inflammatory responses were compared between wild-type (wt) and CD131-deficient mice.
  • Clinical data and pathology specimens from UC patients were analyzed.

Main Results:

  • CD131 was found to contribute to DSS-induced murine colitis, acting in synergy with tissue-infiltrating macrophages.
  • CD131 may promote the chemotaxis of macrophages and T cells into the colon via CCL4.
  • In UC patients, CD131 expression correlated with the severity of intestinal inflammation.

Conclusions:

  • CD131 is implicated in the pathogenesis of ulcerative colitis.
  • The study provides novel insights into the mechanisms of GM-CSF and IL-3 in intestinal inflammation.
  • Understanding CD131's role may aid in developing new therapeutic strategies for UC.