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Published on: September 1, 2016
Rifampicin-associated intravascular haemolysis causing acute kidney injury
P Aravindhmozhi1, Tanuj Moses Lamech2, Charankumar Swamikkannu1
1Department of Nephrology Madras Medical College, Chennai, Tamil Nadu, India.
None:
Drug-induced acute kidney injury (AKI) is a rare adverse effect of rifampicin, and is mostly related to acute tubular necrosis and acute interstitial nephritis. We report a sputum- positive, isoniazid mono-resistant, pulmonary tuberculosis patient who had a history of anti-tuberculous therapy (ATT) intake 30 years ago. The patient developed AKI requiring dialysis when he restarted the ATT recently. A renal biopsy was consistent with pigment-cast nephropathy secondary to rifampicin-induced intravascular haemolysis. Rifampicin was stopped, and the patient underwent a total of four dialysis sessions and subsequently recovered.
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Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

