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Candida parapsilosis endocarditis ın a patient with liver transplantation

Sibel Dogan Kaya1, Aysu Türkmen Karaağaç2

  • 1Department of Infectious Diseases and Clinical Microbiology University of Health Sciences, Kartal Koşuyolu High Specialization Training and Research Hospital, İstanbul, Turkey.

The National Medical Journal of India
|June 30, 2025
PubMed

Insights

Fungal endocarditis, though rare, presents severe complications. This case highlights Candida parapsilosis in a liver transplant patient, emphasizing the need for prompt antifungal treatment.

Area of Science:

  • Cardiovascular Surgery
  • Infectious Diseases
  • Mycology

Background:

  • Infective endocarditis (IE) carries high morbidity and mortality.
  • Fungal endocarditis is a rare but severe complication of IE.
  • Candida parapsilosis is a significant non-albicans species causing fungal endocarditis.

Observation:

  • A 17-year-old liver transplant recipient presented with right heart failure symptoms, including fever, weakness, nausea, and dyspnea.
  • Physical examination revealed pallor, tachycardia, and a systolic ejection murmur.
  • The patient had a history of coronary artery bypass graft and aortic valve replacement.

Findings:

  • Fungal endocarditis caused by Candida species was diagnosed.
  • Antifungal sensitivity testing guided the initiation of Amphotericin B therapy at 4 mg/kg/day.

Implications:

  • This case underscores the importance of considering fungal endocarditis in immunocompromised patients, such as transplant recipients.
  • Prompt diagnosis and targeted antifungal treatment are essential for improving outcomes in severe fungal endocarditis.

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