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Updated: Aug 6, 2026

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
Published on: May 7, 2019
Spasticity complicating metrizamide myelography
Abstract:
Temporary but considerable increase in spasticity following myelography using metrizamide at 300 mgs I/ml concentration occurred in 4 patients. In 3 of the patients the diagnosis is uncertain, but it is likely to be some form of degenerative disease involving motor pathways in two of them; the fourth case has cervical spondylotic myelopathy. The spasticity might be related to the anticholinesterase activity of metrizamide or to competitive inhibition of endogenous glucose metabolism by the deoxyglucose component of the metrizamide molecule.
Insights
Four patients experienced increased spasticity after metrizamide myelography. This temporary effect may be linked to metrizamide
Area of Science:
- Neurology
- Radiology
Background:
- Myelography is an imaging procedure used to examine the spinal cord.
- Metrizamide is a non-ionic contrast agent used in myelography.
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