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Related Concept Videos

Variability: Analysis01:11

Variability: Analysis

192
Measures of variability are statistical metrics that reveal the dispersion pattern within a dataset. They are pivotal in biostatistics, providing insights into the heterogeneity within health and biological data. Variability signifies the degree to which data points diverge from one another, helping researchers understand the potential range of values and associated uncertainty within the data.
The range is a simple measure of variability, indicating the difference between the highest and...
192

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Updated: Sep 17, 2025

Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes
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Clinical application value of different SCC-Ag reference intervals.

Qi Xie1, Longying Zhu1,2, Liang Zhang1

  • 1Department of Clinical Laboratory, First People's Hospital of Linping District, Hangzhou, Hangzhou, Zhejiang Province, People's Republic of China.

Medicine
|June 30, 2025
PubMed
Summary
This summary is machine-generated.

This study establishes a new reference interval for squamous cell carcinoma antigen (SCC-Ag) at ≤2.2 μg/L. This locally tailored interval improves diagnostic accuracy and clinical decision-making for SCC-Ag testing compared to existing standards.

Keywords:
SCC-Agdiagnostic valueshealth checkuppositive ratereference interval

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Area of Science:

  • Clinical Chemistry
  • Tumor Markers
  • Biostatistics

Background:

  • Squamous cell carcinoma antigen (SCC-Ag) is a tumor marker with established reference intervals.
  • Existing SCC-Ag reference intervals may not be optimal for all populations.
  • Accurate reference intervals are crucial for effective cancer screening and diagnosis.

Purpose of the Study:

  • To establish a population-specific reference interval for SCC-Ag.
  • To evaluate the clinical utility of the proposed SCC-Ag reference interval against existing ones.
  • To enhance the accuracy of SCC-Ag testing for clinical decision-making.

Main Methods:

  • Retrospective analysis of 5251 healthy individuals to establish a local SCC-Ag reference interval (≤2.2 μg/L).
  • Evaluation of screening efficacy in 6191 healthy subjects using proposed vs. manufacturer intervals.
  • Assessment of diagnostic performance in 948 patients comparing the two SCC-Ag reference intervals.

Main Results:

  • The proposed SCC-Ag reference interval (≤2.2 μg/L) yielded a lower positive rate (1.696%) in healthy subjects compared to the manufacturer's interval (7.931%).
  • The new interval demonstrated higher specificity, positive predictive value, Youden index, and overall accuracy.
  • Sensitivity and negative predictive value were lower with the proposed interval.

Conclusions:

  • The proposed SCC-Ag reference interval of ≤2.2 μg/L is superior to the manufacturer-provided interval for screening and diagnosis in the studied population.
  • This locally established reference interval offers improved clinical utility and decision-making support.
  • Further validation in diverse populations may be warranted.