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Updated: Sep 17, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Desulfonylative halogenation of arene sulfonyl chlorides using N-halosuccinimides: Synthesis, molecular docking, and
Vikas Yadav1, Rohit Kumar2, Saripella Srikrishna2
1Department of Chemistry, Institute of Science, Banaras Hindu University (BHU), Varanasi, India 221005.
Abstract:
Considering the significant biological potential of halogenated arenes, we developed a novel and eco-friendly method for accessing dihalogenated arenes viaN-halosuccinimide-promoted desulfonylative halogenation of arenesulfonyl chlorides under metal-free conditions. In silico evaluations of selected compounds for amyloid-beta (Aβ) protein interactions identified compounds 1d and 2d as promising candidates, exhibiting strong binding potential and low toxicity in wild-type Oregon R flies. Furthermore, these compounds demonstrated significant neuroprotective activity in an Aβ-induced Alzheimer's disease model in Drosophila, emphasizing the need for further studies in higher organisms and detailed mechanistic investigations.
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