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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Related Experiment Video

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Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors
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Synthesis, Characterization, and In Vitro Properties of Zwitterionic Dendrimers with a Reactive Focal Functionality

Mingxuan Zhang1, Masoud Zamani1, Yafei Su2

  • 1Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260, United States.

Langmuir : the ACS Journal of Surfaces and Colloids
|June 30, 2025
PubMed
Summary

Novel zwitterionic dendrimers (ZDs) with a single reactive group were synthesized. These biocompatible ZDs show potential for antifouling properties and minimized interactions, making them promising for drug delivery applications.

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Nanotechnology

Background:

  • Zwitterionic dendrimers (ZDs) offer tunable properties for biomedical applications.
  • Their charge-neutral, hydrated outer layers suggest excellent antifouling and biocompatibility.
  • Incorporating degradable structures and reactive groups enhances ZD versatility.

Purpose of the Study:

  • To design, synthesize, and characterize novel ZDs with a single focal reactive group.
  • To evaluate the in vitro properties, including biocompatibility and cellular interactions, of these ZDs.
  • To explore the potential of these functionalized ZDs in biomedical applications, particularly therapeutic delivery.

Main Methods:

  • Divergent synthesis utilizing thiol-ene and esterification reactions.
  • Azido-functionalized diene core and sulfobetaine-containing thiol for terminal functionalization.
  • Characterization by 1H NMR, MALDI-TOF MS, and in vitro cytotoxicity assays.

Main Results:

  • Successfully synthesized ZDs with hydrolyzable ester domains and numerous sulfobetaine terminals.
  • Confirmed chemical structure, molecular weight, and structural integrity.
  • Demonstrated noncytotoxicity at 1000 μg/mL and minimal cellular uptake in vitro.
  • Showcased dye incorporation for potential tracking or functionalization.

Conclusions:

  • Feasibility of synthesizing functional ZDs with a single reactive focal point is established.
  • The synthesized ZDs exhibit high biocompatibility and minimized cellular interactions.
  • These ZDs hold significant promise for advanced biomedical applications, including targeted therapeutic delivery systems.