Fundus findings in Leber's hereditary optic neuroretinopathy

The acute stage of Leber's hereditary optic neuritis is characterized by dilated disc arterioles accompanied, in some cases, by superficial peripapillary hemorrhages. Decreased vision caused by centrocecal scotoma is accompanied by slow and deficient capillary filling in the papillomacular bundle and arteriovenous shunting in the upper and lower vascular arcades. These and other vascular changes disappear in the more advanced stages (optic atrophy) of the disease.