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Effects of close surgical margins on prognosis and recurrence of oral squamous cell carcinoma

  • 0Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bengaluru, India.
Journal of the Korean Association of Oral and Maxillofacial Surgeons +

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July 1, 2025

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July 1, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Close surgical margins in oral squamous cell carcinoma (OSCC) significantly increase the risk of recurrence and fatality. Monitoring margins closely is crucial for predicting patient outcomes in OSCC treatment.

Area Of Science

  • Oncology
  • Surgical Pathology

Background

  • Oral squamous cell carcinoma (OSCC) is a prevalent malignancy.
  • Surgical margins are critical in determining cancer treatment outcomes.

Purpose Of The Study

  • To evaluate the association between close surgical margins and the recurrence and prognosis of OSCC.
  • To identify the predictive value of surgical margin status in OSCC patients.

Main Methods

  • Retrospective analysis of 198 patients diagnosed with OSCC.
  • Patients underwent wide local tumor resection and neck dissection with adjuvant therapies.
  • Key variables included pathological stage, tumor size, margin status, and lymph node involvement.

Main Results

  • Close surgical margins were significantly linked to increased disease fatality.
  • Recurrence rates were higher with close margins, particularly within the first two years post-surgery.
  • Tumor stage, size, and lymph node status correlated significantly with margin status.

Conclusions

  • Close surgical margins are a significant predictor of poor prognosis in OSCC.
  • Adherence to adequate surgical margins is vital for improving patient survival rates in OSCC.

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