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Related Experiment Video

Updated: Jun 25, 2026

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

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Anisotropic Magnetic Heating for Adaptive Thermal Ablation.

Sangmo Liu¹, Haopu Liang², Zonghu Han³

¹Department of Chemistry, University of California, Riverside, 501 Big Springs Rd., Riverside, CA, 92521, USA.

Advanced Materials (Deerfield Beach, Fla.)

|July 1, 2025

Summary

This study presents an adaptive thermal ablation probe using aligned nanorods for precise magnetic heating. This innovation enhances safety and efficacy in treating cardiovascular conditions by minimizing damage to healthy tissues.

Keywords:

magnetic nanorods nanocomposites thermal ablation

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Published on: January 13, 2023

Area of Science:

Biomedical Engineering
Materials Science
Nanotechnology

Background:

Thermal ablation is a minimally invasive treatment for cardiovascular and cerebrovascular diseases.
Current methods risk damaging healthy tissues due to poor imaging contrast between diseased and healthy areas.

Purpose of the Study:

To develop an adaptive thermal ablation probe for precise and safe tissue treatment.
To leverage anisotropic magnetic heating of aligned magnetite nanorods to control heat generation.

Main Methods:

An adaptive probe was designed using a bimorph structure with aligned magnetite nanorods in a polymer substrate.
Magnetic fields (static and alternating) were used for pre-alignment of nanorods and probe actuation.
The probe's ability to modulate heat generation by adjusting nanorod orientation was investigated.

Main Results:

The probe demonstrated anisotropic magnetic heating, generating different heat levels along the nanorod aggregates' easy and hard axes.
In vitro experiments showed successful thrombus phantom ablation in fluid flow and porcine artery models.
Healthy tissue viability was preserved during ablation procedures.

Conclusions:

The adaptive thermal ablation probe offers a safer, more precise, and controllable method for treating cardiovascular conditions.
The technology shows significant potential for clinical translation in minimally invasive therapies.
Anisotropic magnetic heating provides a novel mechanism for targeted thermal therapy.