Related Experiment Video
Updated: Jun 25, 2026
09:01
Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
Published on: May 22, 2020
3.2K
Anisotropic Magnetic Heating for Adaptive Thermal Ablation.
Sangmo Liu1, Haopu Liang2, Zonghu Han3
1Department of Chemistry, University of California, Riverside, 501 Big Springs Rd., Riverside, CA, 92521, USA.
Advanced Materials (Deerfield Beach, Fla.)
|July 1, 2025
Summary
This study presents an adaptive thermal ablation probe using aligned nanorods for precise magnetic heating. This innovation enhances safety and efficacy in treating cardiovascular conditions by minimizing damage to healthy tissues.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Thermal ablation is a minimally invasive treatment for cardiovascular and cerebrovascular diseases.
- Current methods risk damaging healthy tissues due to poor imaging contrast between diseased and healthy areas.
Purpose of the Study:
- To develop an adaptive thermal ablation probe for precise and safe tissue treatment.
- To leverage anisotropic magnetic heating of aligned magnetite nanorods to control heat generation.
Main Methods:
- An adaptive probe was designed using a bimorph structure with aligned magnetite nanorods in a polymer substrate.
- Magnetic fields (static and alternating) were used for pre-alignment of nanorods and probe actuation.
- The probe's ability to modulate heat generation by adjusting nanorod orientation was investigated.
Main Results:
- The probe demonstrated anisotropic magnetic heating, generating different heat levels along the nanorod aggregates' easy and hard axes.
- In vitro experiments showed successful thrombus phantom ablation in fluid flow and porcine artery models.
- Healthy tissue viability was preserved during ablation procedures.
Conclusions:
- The adaptive thermal ablation probe offers a safer, more precise, and controllable method for treating cardiovascular conditions.
- The technology shows significant potential for clinical translation in minimally invasive therapies.
- Anisotropic magnetic heating provides a novel mechanism for targeted thermal therapy.
More Related Videos
06:45In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System
Published on: July 2, 2020
4.4K
13:41Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
Published on: January 13, 2023
2.5K
Related Concept Videos
01:19Mechanism of heat transfer
Understanding heat transfer mechanisms is essential for understanding how our bodies maintain balance in different environmental conditions. When the environment is thermoneutral, the body is in a state of balance, neither using nor releasing energy to maintain its core temperature. However, when the environment is not thermoneutral, the body employs four heat transfer mechanisms to maintain homeostasis: conduction, convection, evaporation, and radiation. These mechanisms facilitate heat...
01:20Mechanisms of Heat Transfer II
In convection, thermal energy is carried by the large-scale flow of matter. Ocean currents and large-scale atmospheric circulation, which result from the buoyancy of warm air and water, transfer hot air from the tropics toward the poles and cold air from the poles toward the tropics. The Earth’s rotation interacts with those flows, causing the observed eastward flow of air in the temperate zones. Convection dominates heat transfer by air, and the amount of available space for the airflow...
01:28Types Of Superconductors
A superconductor is a substance that offers zero resistance to the electric current when it drops below a critical temperature. Zero resistance is not the only interesting phenomenon as materials reach their transition temperatures. A second effect is the exclusion of magnetic fields. This is known as the Meissner effect. A light, permanent magnet placed over a superconducting sample will levitate in a stable position above the superconductor. High-speed trains that levitate on strong...
01:31Ferromagnetism
Materials like iron, nickel, and cobalt consist of magnetic domains, within which the magnetic dipoles are arranged parallel to each other. The magnetic dipoles are rigidly aligned in the same direction within a domain by quantum mechanical coupling among the atoms. This coupling is so strong that even thermal agitation at room temperature cannot break it. The result is that each domain has a net dipole moment. However, some materials have weaker coupling, and are ferromagnetic at lower...
01:31Magnetic Susceptibility and Permeability
In linear magnetic materials, like paramagnets and diamagnets, magnetization is proportional to the magnetic field intensity. The constant of proportionality, a dimensionless number, is called magnetic susceptibility. The value of the susceptibility depends on the type of material.
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
01:14Mechanisms of Heat Transfer
Heat transfer between the human body and its environment occurs through four main mechanisms: conduction, convection, radiation, and evaporation.
Conduction, accounting for approximately 3% of body heat loss at rest, is the process of exchanging heat between molecules of two materials in direct contact. This can result in both heat loss and gain. For instance, when the body is submerged in water, which conducts heat 20 times more effectively than air, it can either lose or gain significant heat.
Conduction, accounting for approximately 3% of body heat loss at rest, is the process of exchanging heat between molecules of two materials in direct contact. This can result in both heat loss and gain. For instance, when the body is submerged in water, which conducts heat 20 times more effectively than air, it can either lose or gain significant heat.