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Updated: Sep 17, 2025

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
Metabolic-Associated Steatotic Liver Disease: From Molecular Mechanisms to Novel Therapies
John Cooper1, Parth Patel1, Joven Tristeza1
1Internal Medicine, University of Alabama, Birmingham, Alabama, USA.
Abstract:
Metabolic-associated steatotic liver disease (MASLD) is a burgeoning worldwide burden and is currently the leading indication for a liver transplant. Despite the growing burden of disease, there are few pharmacological treatments available. The underlying molecular mechanisms of the development of MASLD are still being elucidated. In this review, we will summarize the known molecular mechanisms in the development of MASLD along with past, current, and future pharmacologic clinical trials.
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