Related Experiment Video
Updated: Sep 17, 2025
Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
Published on: August 24, 2019
Ulcerative colitis combined with isolated superficially serrated adenoma: a Case Report
Hua Gao1, Jinshan Nie1, Lipin Zhang2
1Department of Gastroenterology, Taicang Affiliated Hospital of Soochow University, The First People's Hospital of Taicang, Taicang, Jiangsu, China.
Introduction:
Superficially serrated adenoma (SuSA) is a recently identified type of serrated lesion characterized by a combination of adenomatous and serrated features. There are limited reports on SuSA currently, and its occurrence in conjunction with ulcerative colitis (UC) has not yet been documented.
Case Presentation:
We present the case of a 38-year-old male with a 13-year history of ulcerative colitis (UC). During a routine follow-up colonoscopy, a superficial elevated lesion with a whitish surface was detected in the rectum, 10 cm from the anal verge. The lesion was removed en bloc via endoscopic submucosal dissection (ESD). Pathological analysis showed a combination of superficial serrated and vertically oriented adenomatoid glands. Immunohistochemistry indicated that the superficial epithelial cells exhibited serrated features and expressed CK20, while the middle and lower mucosal layers tested positive for Ki-67.
Conclusion:
Although some studies have explored SuSA, many aspects of the disease remain unclear. This is the first reported case of UC combined with SuSA. Future reports are essential to enhance understanding of the potential link between UC and SuSA.
Related Concept Videos
01:21Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...