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Ten tips for an onco-nephrology clinic
Elena-Bianca Barbir1,2, Nelson Leung1, Sandra M Herrmann1
1Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Clinical Kidney Journal
|July 1, 2025
Summary
Oncology patients often experience kidney toxicity from cancer treatments. Onco-nephrology expertise is crucial for managing acute kidney injury and optimizing cancer therapy during kidney dysfunction.
Area of Science:
- Oncology
- Nephrology
- Pharmacology
Background:
- Modern cancer therapies, including chemotherapy, targeted agents, and cellular therapies, are associated with significant adverse events.
- Kidney toxicity (nephrotoxicity) is a common and serious side effect of many anti-cancer treatments.
- The increasing complexity of cancer care necessitates specialized expertise in managing treatment-related kidney complications.
Purpose of the Study:
- To provide practical guidance for managing kidney-related issues in cancer patients undergoing therapy.
- To highlight the growing importance of onco-nephrology in multidisciplinary cancer care.
- To outline key considerations for oncologists and nephrologists managing patients with cancer and kidney dysfunction.
Main Methods:
- Review of common clinical scenarios encountered in an outpatient onco-nephrology setting.
- Integration of principles from oncology, nephrology, and pharmacology.
- Development of 10 practical tips for clinical application.
Main Results:
- Identification of critical areas where onco-nephrology consultation is essential.
- Strategies for assessing glomerular filtration rate in special populations.
- Guidance on supportive care for acute kidney injury during cancer treatment.
- Pharmacologic approaches to enable continuation or reinitiation of cancer therapy despite kidney dysfunction.
Conclusions:
- Onco-nephrology collaboration is vital for optimizing cancer treatment outcomes and patient safety.
- Effective management of kidney toxicity can prevent treatment delays or discontinuation.
- Specialized onco-nephrology expertise improves the care of cancer patients with or at risk of kidney disease.
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