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Updated: Sep 8, 2025

Conventional BODIPY Conjugates for Live-Cell Super-Resolution Microscopy and Single-Molecule Tracking
Published on: June 8, 2020
α-Amination at BODIPY and BOPHY Core via Metal-Free Regiospecific Cross Dehydrogenative Coupling Reaction Toward the
Kartik Dutta1, Richa Agrawal1,2, Nitish Chauhan1,2
1Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
Abstract:
We report a metal-free, efficient, and quick cross dehydrogenative coupling (CDC) methodology using phenyliodine(III) diacetate (PIDA) as an oxidant to synthesize regiospecific α-amino BODIPYs/BOPHYs via C(sp2)-N(sp3) bond formation. Twenty-seven coupled products were synthesized using different primary/secondary amines and commercial drug molecules. The regiospecificity and mechanism of the reactions were confirmed by NMR, EPR, HRMS, and X-ray crystallography studies. One of the synthesized molecules, BODIPY 3t, showed an excellent lysosome targeting ability with turn-on fluorescence inside the lysosome, making it an efficient Lysotracker agent.
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