Related Experiment Video
Updated: Jun 13, 2026
11:20
An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
Published on: August 30, 2017
7.5K
Recent advances in upconversion nanoparticles for biomolecule detection: a review.
Shuoshuo Cheng1, Bin Huang1, Kangqiang Lu1
1Jiangxi Provincial Key Laboratory of Functional Crystalline Materials Chemistry, School of Chemistry and Chemical Engineering, Jiangxi University of Science and Technology, Ganzhou, 341000, P. R. China. jialinz2007@163.com.
Summary
Upconversion nanoparticles (UCNPs) offer sensitive biomolecule detection through advanced synthesis and surface functionalization. This review explores UCNP applications, enhancing biological detection methods.
Area of Science:
- Nanotechnology
- Biochemistry
- Analytical Chemistry
Background:
- Biological detection demands are increasing.
- Upconversion nanoparticle (UCNP)-based techniques provide a novel research direction.
- UCNPs offer superior and stable photophysical characteristics for sensitive biomolecule detection.
Purpose of the Study:
- To review articles on UCNP synthesis, surface functionalization, and application in biomolecule detection.
- To summarize and compare advantages and disadvantages of UCNP synthesis methods.
- To analyze UCNP shortcomings and present future prospects.
Main Methods:
- Review of synthesis methods including control of size, shape, and doping.
- Discussion of surface modification approaches: silanization, ligand exchange, oxidation, attraction, and layer-by-layer assembly.
- Focus on UCNP-based luminescence sensors for detecting nucleic acids, amino acids, proteins, carbohydrates, uric acid, and lipids.
Main Results:
- UCNPs serve as carriers for recognition, transmission, and signal amplification.
- UCNP applications significantly improve biomolecule detection performance.
- Various synthesis and functionalization methods enable tailored UCNP properties.
Conclusions:
- UCNPs are crucial elements for advanced biomolecule detection.
- Further research into UCNP synthesis and functionalization will drive innovation.
- UCNP technology holds significant promise for future biological detection.
